Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 9/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.32 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200898 | 0.92 | TOP1 (0.37) | TOP1ENPP2ATXN2KDM4EALDH1A1 | |
| SCHEMBL1972738 | 0.91 | KDM4E (0.40) | TOP1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL12427373 | 0.85 | TOP1 (0.39) | TOP1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL5177876 | 0.85 | KDM4E (0.37) | TOP1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL1974585 | 0.83 | TOP1 (0.35) | TOP1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL2198753 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1POLBTDP1LMNA | |
| SCHEMBL1972428 | 0.83 | KDM4E (0.39) | TOP1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL12427378 | 0.81 | TOP1 (0.37) | TOP1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL5275382 | 0.81 | KDM4E (0.35) | TOP1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL5178884 | 0.80 | KDM4E (0.35) | TOP1KDM4EALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994020-B1 | Substituted quinolones III | AICURIS GMBH & CO KG (DE) | 2011-06-22 | — | — | EP | disclosed |