Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 16/20 | 0.77 |
| ▸ | AKT1 | P31749 | 4/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | JAK1 | P23458 | 2/20 | 0.50 |
| ▸ | TYK2 | P29597 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1975450 | 0.90 | AKT2 (0.80) | AKT2AKT1CYP2C9ROCK2KCNH2 | |
| SCHEMBL16105745 | 0.88 | AKT2 (0.76) | AKT2AKT1CYP2C9ROCK2KCNH2 | |
| SCHEMBL1001963 | 0.87 | AKT2 (1.00) | AKT2AKT1CYP2C9ROCK2KCNH2 | |
| SCHEMBL1974534 | 0.82 | AKT2 (0.77) | AKT2AKT1CYP2C9ROCK2KCNH2 | |
| SCHEMBL1968905 | 0.81 | AKT2 (0.61) | AKT2AKT1CYP2C9ROCK2KCNH2 | |
| SCHEMBL1975865 | 0.80 | AKT2 (0.76) | AKT2AKT1CYP2C9ROCK2KCNH2 | |
| SCHEMBL1970926 | 0.79 | AKT2 (0.77) | AKT2AKT1CYP2C9ROCK2KCNH2 | |
| SCHEMBL1973751 | 0.78 | AKT2 (0.77) | AKT2AKT1CYP2C9ROCK2KCNH2 | |
| SCHEMBL1003173 | 0.78 | AKT2 (1.00) | AKT2AKT1CYP2C9ROCK2KCNH2 | |
| SCHEMBL1002396 | 0.78 | AKT2 (1.00) | AKT2AKT1CYP2C9ROCK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812004-B1 | ORTHO- CONDENSED PYRIDINE AND PYRIMIDINE DERIVATIVES (E. G. PURINES) AS PROTEIN KINASES INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2011-06-22 | — | — | EP | claimed |