Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 15/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.43 |
| ▸ | MTOR | P42345 | 9/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19736618 | 0.83 | PIK3CD (0.44) | PIK3CDPIK3C2BPIK3CGPIK3CBMTOR | |
| SCHEMBL21078709 | 0.81 | PIK3CD (0.44) | PIK3CDPIK3C2BPIK3CGPIK3CBMTOR | |
| SCHEMBL19736616 | 0.78 | PIK3CD (0.48) | PIK3CDPIK3C2BPIK3CGPIK3CBMTOR | |
| SCHEMBL19736868 | 0.78 | PIK3CD (0.48) | PIK3CDPIK3C2BPIK3CGPIK3CBMTOR | |
| SCHEMBL19736644 | 0.77 | PIK3CD (0.61) | PIK3CDPIK3C2BPIK3CGPIK3CBMTOR | |
| SCHEMBL19736880 | 0.77 | PIK3CD (0.60) | PIK3CDPIK3C2BPIK3CGPIK3CBMTOR | |
| SCHEMBL19736721 | 0.76 | PIK3CD (0.48) | PIK3CDPIK3C2BPIK3CGPIK3CBMTOR | |
| SCHEMBL19736878 | 0.76 | PIK3CD (0.49) | PIK3CDPIK3C2BPIK3CGPIK3CBMTOR | |
| SCHEMBL19736617 | 0.75 | PIK3CD (0.45) | PIK3CDPIK3C2BPIK3CGPIK3CBMTOR | |
| SCHEMBL19736863 | 0.74 | SUV39H2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472160-B1 | BICYCLIC PYRIDINE, PYRAZINE, AND PYRIMIDINE DERIVATIVES AS PI3K BETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-02-24 | — | — | EP | disclosed |
| WO-2017216292-A1 | BICYCLIC PYRIDINE, PYRAZINE, AND PYRIMIDINE DERIVATIVES AS PI3K BETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-12-21 | — | — | WO | disclosed |