Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19736615 | 0.87 | SLC2A1 (0.44) | SLC2A1ENPP2PIK3CAMTORMAPT | |
| SCHEMBL19736839 | 0.84 | SLC2A1 (0.46) | SLC2A1ENPP2PIK3CAMTORMAPT | |
| SCHEMBL19736821 | 0.82 | SLC2A1 (0.41) | SLC2A1ENPP2PIK3CAMTORMAPT | |
| SCHEMBL19736707 | 0.82 | SLC2A1 (0.47) | SLC2A1ENPP2PIK3CAMTORMAPT | |
| SCHEMBL19736844 | 0.81 | AKT1 (0.46) | SLC2A1ENPP2PIK3CAMAPTALDH1A1 | |
| SCHEMBL19736645 | 0.76 | PIK3CD (0.52) | SLC2A1MTORMAPTTP53KDM4E | |
| SCHEMBL19736643 | 0.74 | PIK3C2B (0.58) | PIK3CAMTOR | |
| SCHEMBL19736705 | 0.74 | SLC2A1 (0.46) | SLC2A1ENPP2PIK3CAMTORMAPT | |
| SCHEMBL19495214 | 0.73 | SLC2A1 (0.54) | SLC2A1ENPP2MAPTTP53ALDH1A1 | |
| SCHEMBL19736841 | 0.73 | AKT1 (0.44) | SLC2A1ENPP2MAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472160-B1 | BICYCLIC PYRIDINE, PYRAZINE, AND PYRIMIDINE DERIVATIVES AS PI3K BETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-02-24 | — | — | EP | disclosed |
| WO-2017216292-A1 | BICYCLIC PYRIDINE, PYRAZINE, AND PYRIMIDINE DERIVATIVES AS PI3K BETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-12-21 | — | — | WO | disclosed |