Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | NPC1 | O15118 | 5/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 3/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.75 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | USP2 | O75604 | 2/20 | 0.71 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.70 |
| ▸ | TP53 | P04637 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19737573 | 0.94 | MAPT (0.88) | MAPTMEN1KMT2ANPC1MCL1 | |
| SCHEMBL21087862 | 0.92 | MAPT (0.84) | MAPTMEN1KMT2ANPC1MCL1 | |
| SCHEMBL14955150 | 0.91 | MAPT (0.83) | MAPTMEN1KMT2ANPC1MCL1 | |
| SCHEMBL22130983 | 0.91 | MAPT (0.83) | MAPTMEN1KMT2ANPC1MCL1 | |
| SCHEMBL19737749 | 0.91 | MAPT (0.83) | MAPTMEN1KMT2ANPC1MCL1 | |
| SCHEMBL19737515 | 0.88 | MAPT (0.78) | MAPTMEN1KMT2ANPC1MCL1 | |
| SCHEMBL19737753 | 0.88 | MAPT (0.78) | MAPTMEN1KMT2ANPC1MCL1 | |
| SCHEMBL19737725 | 0.85 | MAPT (0.79) | MAPTMEN1KMT2ANPC1MCL1 | |
| SCHEMBL19737750 | 0.85 | MAPT (0.75) | MAPTMEN1KMT2ANPC1MCL1 | |
| SCHEMBL21051647 | 0.85 | MAPT (0.74) | MAPTMEN1KMT2ANPC1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017217439-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | 国立大学法人東京大学 | 2017-12-21 | — | — | WO | disclosed |