Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.84 |
| ▸ | BACE2 | Q9Y5Z0 | 20/20 | 0.84 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.75 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.75 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.75 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.75 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.75 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1974893 | 1.00 | BACE1 (0.84) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL1976053 | 0.92 | BACE1 (1.00) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL1975877 | 0.90 | BACE1 (1.00) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL1974290 | 0.88 | BACE1 (0.78) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL1972975 | 0.88 | BACE1 (1.00) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL1972644 | 0.88 | BACE1 (0.78) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL1978333 | 0.88 | BACE1 (0.78) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL1974838 | 0.87 | BACE1 (0.82) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL2596011 | 0.87 | BACE1 (0.85) | BACE1BACE2 | |
| SCHEMBL1974844 | 0.87 | BACE1 (0.82) | BACE1BACE2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389513-B2 | 2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides | HOFFMANN-LA ROCHE INC. (US) | 2013-03-05 | — | — | US | claimed |
| US-20110144097-A1 | 2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | US | claimed |
| US-9073909-B2 | [1,3]oxazines | HOFFMANN-LA ROCHE INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073909-B2 | [1,3]oxazines | HOFFMANN-LA ROCHE INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140112867-A1 | [1,3]OXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | US | disclosed |
| US-20140112867-A1 | [1,3]OXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | US | disclosed |
| US-8389513-B2 | 2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides | HOFFMANN-LA ROCHE INC. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389513-B2 | 2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides | HOFFMANN-LA ROCHE INC. (US) | 2013-03-05 | — | — | US | disclosed |
| WO-2011069934-A1 | 2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |
| US-20110144097-A1 | 2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | US | disclosed |
| US-20110144097-A1 | 2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140112867-A1 | [1,3]OXAZINES | BACE2, BACE1, APP | BACE1 2/4885BACE2 1/4885PSEN1 4/4885 |
| US-20110144097-A1 | 2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES | BACE2, BACE1, APP | BACE1 2/4885BACE2 1/4885PSEN1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.