Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736535 | 0.89 | NPC1 (0.46) | NPC1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL19742250 | 0.83 | PLK1 (0.43) | NPC1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL15253960 | 0.74 | PLK1 (0.69) | SMN1; SMN2MAPTKMT2AALDH1A1LMNA | |
| SCHEMBL5171763 | 0.74 | MAPT (0.42) | NPC1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL19742275 | 0.73 | NPC1 (0.44) | NPC1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL9735443 | 0.71 | PLK1 (0.55) | NPC1SMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL7587421 | 0.70 | NPC1 (0.51) | NPC1SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL7591886 | 0.69 | NPC1 (0.50) | NPC1SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL28057357 | 0.69 | NPC1 (0.50) | NPC1SMN1; SMN2MAPTALDH1A1TDP1 | |
| SCHEMBL7791316 | 0.68 | SMN1; SMN2 (0.64) | NPC1SMN1; SMN2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170369470-A1 | Cyclic Compounds and Uses Thereof | Karyopharm Therapeutics Inc. | 2017-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369470-A1 | Cyclic Compounds and Uses Thereof | MALT1, BCL9, BCL6 | NPC1 1213/4885SMN1; SMN2 1589/4885MAPT 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.