Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | PRKACA | P17612 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 3/20 | 0.38 |
| ▸ | GSK3A | P49840 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2537071 | 0.77 | CHEK1 (0.61) | CHEK1LRRK2TRPA1PRKD3MAP4K4 | |
| SCHEMBL22912722 | 0.76 | CHEK1 (0.66) | CHEK1LRRK2TRPA1PDPK1PRKD3 | |
| SCHEMBL2544061 | 0.76 | IRAK4 (0.57) | CHEK1CLK2CLK4IRAK4IRAK1 | |
| SCHEMBL27457717 | 0.76 | EGFR (0.57) | CHEK1LRRK2TRPA1MAP4K4PRKACA | |
| SCHEMBL6260067 | 0.75 | CDK1 (0.50) | CHEK1LRRK2TRPA1PDPK1PRKD3 | |
| SCHEMBL397485 | 0.75 | CHEK1 (0.63) | CHEK1LRRK2TRPA1PRKD3MAP4K4 | |
| SCHEMBL19913251 | 0.74 | LRRK2 (0.42) | LRRK2PDPK1PRKD3MAP4K4PRKACA | |
| SCHEMBL27909334 | 0.74 | BTK (0.53) | — | |
| SCHEMBL27457718 | 0.74 | AKT1 (0.53) | CHEK1LRRK2PRKD3MAP4K4PRKACA | |
| SCHEMBL61206 | 0.73 | CHEK1 (1.00) | CHEK1LRRK2TRPA1DYRK1ASTK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472165-A1 | N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2019-04-24 | — | — | EP | disclosed |
| WO-2017220477-A1 | N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-12-28 | — | — | WO | disclosed |