Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 16/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19746714 | 1.00 | HDAC6 (0.44) | HDAC6HDAC8HDAC1HDAC5HDAC4 | |
| SCHEMBL19746368 | 0.85 | HDAC4 (0.56) | HDAC6HDAC8HDAC1HDAC5HDAC4 | |
| SCHEMBL19747128 | 0.85 | HDAC6 (0.46) | HDAC6HDAC8HDAC1HDAC5HDAC4 | |
| SCHEMBL19746213 | 0.83 | HDAC4 (0.46) | HDAC6HDAC8HDAC1HDAC5HDAC4 | |
| SCHEMBL19746871 | 0.83 | HDAC4 (0.47) | HDAC6HDAC8HDAC1HDAC5HDAC4 | |
| SCHEMBL19747032 | 0.81 | HDAC6 (0.48) | HDAC6HDAC8HDAC1HDAC5HDAC4 | |
| SCHEMBL19747214 | 0.77 | HDAC6 (0.67) | HDAC6HDAC8HDAC1HDAC5HDAC4 | |
| SCHEMBL19746657 | 0.77 | HDAC6 (0.47) | HDAC6HDAC8HDAC1HDAC5HDAC4 | |
| SCHEMBL19746589 | 0.75 | HDAC6 (0.45) | HDAC6HDAC8HDAC1HDAC5HDAC4 | |
| SCHEMBL19746096 | 0.75 | HDAC6 (0.47) | HDAC6HDAC8HDAC1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017222952-A1 | 3- HETEROARYL SUBSTITUTED 5-TRIFLUOROMETHYL OXADIAZOLES AS HISTONE DEACETYLASE 6 (HDAC6) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-12-28 | — | — | WO | claimed |