Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.74 |
| ▸ | THRB | P10828 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | TP53 | P04637 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | STAT3 | P40763 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19747409 | 0.88 | PCSK9 (0.78) | PCSK9RXFP1THRBSMN1; SMN2TP53 | |
| SCHEMBL19746581 | 0.83 | PCSK9 (0.70) | PCSK9RXFP1THRBSMN1; SMN2TP53 | |
| SCHEMBL21981110 | 0.82 | MAPT (0.74) | PCSK9RXFP1SMN1; SMN2TP53MAPT | |
| SCHEMBL19746324 | 0.81 | NPC1 (0.76) | PCSK9SMN1; SMN2TP53MAPTHPGD | |
| SCHEMBL31613770 | 0.81 | NPC1 (0.76) | PCSK9SMN1; SMN2TP53MAPTHPGD | |
| SCHEMBL19746668 | 0.80 | PCSK9 (0.66) | PCSK9RXFP1THRBSMN1; SMN2TP53 | |
| SCHEMBL17705604 | 0.79 | MAPT (0.75) | PCSK9RXFP1SMN1; SMN2TP53MAPT | |
| SCHEMBL3484478 | 0.79 | MAPT (0.74) | PCSK9RXFP1SMN1; SMN2TP53MAPT | |
| SCHEMBL15798260 | 0.78 | NPC1 (1.00) | PCSK9SMN1; SMN2TP53MAPTHPGD | |
| SCHEMBL2245512 | 0.78 | MAPT (0.82) | RXFP1THRBSMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3471714-B1 | ANTI-PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (ANTI-PCSK9) COMPOUNDS AND METHODS OF USING THE SAME IN THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES | SHIFA BIOMEDICAL CORP (US) | 2025-06-11 | — | — | EP | claimed |
| CN-109475521-B | Anti-proprotein convertase subtilisin Kexin type 9 (anti-PCSK 9) compounds and methods of use thereof for treating and/or preventing cardiovascular diseases | 实发生物医学公司 | 2022-11-15 | — | — | CN | claimed |
| US-10899748-B2 | Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases | SHIFA BIOMEDICAL CORPORATION (US) | 2021-01-26 | — | — | US | claimed |
| US-20200262822-A1 | Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases | SHIFA BIOMEDICAL CORPORATION | 2020-08-20 | — | — | US | claimed |
| US-20190270729-A1 | Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-09-05 | — | — | US | claimed |
| EP-3471714-A1 | ANTI-PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (ANTI-PCSK9) COMPOUNDS AND METHODS OF USING THE SAME IN THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES | Shifa Biomedical Corporation (US) | 2019-04-24 | — | — | EP | claimed |
| WO-2017222953-A1 | ANTI-PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (ANTI-PCSK9) COMPOUNDS AND METHODS OF USING THE SAME IN THE TREATMENT AND/OR PREVENTION OF CARDIOVASCULAR DISEASES | SHIFA BIOMEDICAL CORPORATION (US) | 2017-12-28 | — | — | WO | claimed |
| US-20220073647-A1 | APPLICATION OF PCSK9 INHIBITORS IN THE PREPARATION OF DRUGS FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES | CHEN MIN (CN) | 2022-03-10 | — | — | US | disclosed |
| US-11214625-B2 | Application of PCSK9 inhibitors in the preparation of drugs for the treatment of inflammatory immune diseases | CHEN MIN (CN) | 2022-01-04 | — | — | US | disclosed |
| US-10947220-B2 | Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases | SHIFA BIOMEDICAL CORPORATION (US) | 2021-03-16 | — | — | US | disclosed |
| US-20200262822-A1 | Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases | SHIFA BIOMEDICAL CORPORATION | 2020-08-20 | — | — | US | disclosed |
| US-20190270729-A1 | Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10899748-B2 | Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases | PCSK9, PCSK6, PCSK7 | PCSK9 1/4885RXFP1 1160/4885THRB 2065/4885 |
| US-20220073647-A1 | APPLICATION OF PCSK9 INHIBITORS IN THE PREPARATION OF DRUGS FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES | PCSK9, PCSK6, PCSK7 | PCSK9 1/4885RXFP1 3768/4885THRB 3996/4885 |
| US-20200262822-A1 | Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases | PCSK9, PCSK6, PCSK7 | PCSK9 1/4885RXFP1 1160/4885THRB 2065/4885 |
| US-11214625-B2 | Application of PCSK9 inhibitors in the preparation of drugs for the treatment of inflammatory immune diseases | PCSK9, PCSK6, PCSK7 | PCSK9 1/4885RXFP1 3788/4885THRB 3981/4885 |
| US-20190270729-A1 | Anti-Proprotein Convertase Subtilisin Kexin Type 9 (Anti-PCSK9) Compounds and Methods of Using the Same in the Treatment and/or Prevention of Cardiovascular Diseases | PCSK9, PCSK6, PCSK7 | PCSK9 1/4885RXFP1 1160/4885THRB 2065/4885 |
| US-10947220-B2 | Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases | PCSK9, PCSK6, PCSK7 | PCSK9 1/4885RXFP1 1160/4885THRB 2065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.