Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.68 |
| ▸ | PDE6A | P16499 | 8/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1969924 | 1.00 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE4BPDE4D | |
| SCHEMBL8376710 | 0.86 | PDE5A (0.76) | PDE5AKCNH2PDE6APDE4BPDE4D | |
| SCHEMBL1971307 | 0.81 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1970051 | 0.80 | PDE5A (0.74) | PDE5AKCNH2PDE6APDE4BPDE4D | |
| SCHEMBL1971532 | 0.80 | PDE5A (1.00) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL1970609 | 0.80 | PDE5A (0.81) | PDE5AKCNH2PDE6APDE11A | |
| SCHEMBL8372818 | 0.79 | PDE5A (0.75) | PDE5AKCNH2PDE6APDE4BPDE4D | |
| SCHEMBL1969644 | 0.79 | PDE5A (0.72) | PDE5AKCNH2PDE6APDE4BPDE4D | |
| SCHEMBL14390803 | 0.79 | PDE5A (0.79) | PDE5AKCNH2PDE6APDE4BPDE4D | |
| SCHEMBL1970644 | 0.78 | PDE5A (0.84) | PDE5AKCNH2PDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013208-B1 | PYRIDIN[3,4-B]PYRAZINONES | PFIZER PROD INC (US) | 2011-06-22 | — | — | EP | disclosed |