Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.83 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.83 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.83 |
| ▸ | RET | P07949 | 1/20 | 0.83 |
| ▸ | MET | P08581 | 1/20 | 0.83 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.83 |
| ▸ | TEC | P42680 | 1/20 | 0.83 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.83 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.83 |
| ▸ | BTK | Q06187 | 1/20 | 0.83 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.83 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21588621 | 0.91 | EGFR (0.82) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL28764348 | 0.91 | EGFR (0.84) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL29707113 | 0.91 | EGFR (0.84) | EGFRERBB2KCNH2RIPK2RET | |
| Poziotinib SCHEMBL29453260 | 0.91 | EGFR (1.00) | EGFRERBB2KCNH2RIPK2RET | |
| Poziotinib SCHEMBL29375341 | 0.91 | EGFR (1.00) | EGFRERBB2KCNH2RIPK2RET | |
| Poziotinib SCHEMBL3391764 | 0.91 | EGFR (1.00) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL22630755 | 0.90 | EGFR (0.90) | EGFRERBB2KCNH2RIPK2RET | |
| Poziotinib SCHEMBL14841985 | 0.90 | EGFR (0.98) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL28458814 | 0.90 | EGFR (0.84) | EGFRERBB2KCNH2RIPK2RET | |
| SCHEMBL22244610 | 0.89 | EGFR (0.86) | EGFRERBB2KCNH2RIPK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948441-B1 | METHOD FOR PREPARING 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY)PIPERIDIN-1-YL)PROP-2-EN-1-ONE | HANMI PHARM IND CO LTD (KR) | 2017-12-27 | — | — | EP | disclosed |