Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16407933 | 0.89 | CYP1A2 (0.39) | CYP1A2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL12733811 | 0.88 | HRH1 (0.43) | CYP1A2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL16407931 | 0.88 | POLB (0.37) | CYP1A2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL16407932 | 0.87 | CYP1A2 (0.39) | CYP1A2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL16407930 | 0.84 | CYP1A2 (0.35) | CYP1A2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL12733812 | 0.81 | APP (0.45) | CYP1A2POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL12733850 | 0.80 | PDE10A (0.40) | CYP1A2KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL12733851 | 0.79 | HSD17B10 (0.39) | CYP1A2POLBKDM4EF2SMN1; SMN2 | |
| SCHEMBL12733789 | 0.79 | HRH1 (0.45) | CYP1A2KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL12733785 | 0.78 | PDE10A (0.40) | CYP1A2POLBKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488513-B1 | 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases | AC IMMUNE SA (CH) | 2017-12-27 | — | — | EP | disclosed |