Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PGK1 | P00558 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19751933 | 0.88 | CYP1A2 (0.84) | APPCYP1A2HRH3LMNAALDH1A1 | |
| SCHEMBL12705205 | 0.82 | APP (1.00) | APPCYP1A2HRH3LMNAALDH1A1 | |
| SCHEMBL12705055 | 0.82 | APP (1.00) | APPCYP1A2HRH3LMNAALDH1A1 | |
| SCHEMBL27513658 | 0.82 | CYP1A2 (1.00) | APPCYP1A2HRH3LMNAALDH1A1 | |
| SCHEMBL6091943 | 0.82 | CYP1A2 (0.69) | APPCYP1A2HRH3LMNAALDH1A1 | |
| SCHEMBL12705295 | 0.82 | APP (0.94) | APPCYP1A2HRH3LMNAALDH1A1 | |
| SCHEMBL12710492 | 0.82 | CYP1A2 (0.69) | APPCYP1A2HRH3LMNAALDH1A1 | |
| SCHEMBL12705207 | 0.82 | CYP1A2 (0.69) | APPCYP1A2HRH3LMNAALDH1A1 | |
| SCHEMBL20917627 | 0.81 | APP (0.47) | APPCYP1A2LMNAALDH1A1NPC1 | |
| SCHEMBL30831190 | 0.81 | APP (0.47) | APPCYP1A2LMNAALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488513-B1 | 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases | AC IMMUNE SA (CH) | 2017-12-27 | — | — | EP | disclosed |