Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196735 | 0.87 | HDAC1 (0.43) | HDAC1HDAC2HDAC3HDAC8HDAC4 | |
| SCHEMBL197709 | 0.87 | HDAC1 (0.61) | HDAC1HDAC2HDAC3HDAC8HDAC4 | |
| SCHEMBL199793 | 0.85 | HDAC1 (0.46) | HDAC1HDAC2HDAC3HDAC8HDAC4 | |
| SCHEMBL197565 | 0.83 | HDAC1 (0.34) | HDAC1HDAC2HDAC3HDAC8HDAC4 | |
| SCHEMBL8292317 | 0.82 | HDAC1 (0.56) | HDAC1HDAC2HDAC3HDAC8NAMPT | |
| SCHEMBL2698871 | 0.82 | HDAC1 (0.41) | HDAC1HDAC2HDAC3HDAC8HDAC4 | |
| SCHEMBL198854 | 0.76 | HDAC1 (0.56) | HDAC1HDAC2HDAC3HDAC8NAMPT | |
| SCHEMBL197426 | 0.76 | HDAC1 (0.58) | HDAC1HDAC2HDAC3HDAC8HDAC4 | |
| SCHEMBL14155991 | 0.74 | HDAC1 (0.63) | HDAC1HDAC2HDAC3HDAC8NAMPT | |
| SCHEMBL3642412 | 0.73 | HDAC1 (0.73) | HDAC1HDAC2HDAC3HDAC8NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198299-B2 | Cycloalkylidene and heterocycloalkylidene inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| US-20120045412-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-02-23 | — | — | US | disclosed |
| US-8088771-B2 | Cycloalkylidene and heterocycloalkylidene inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20100022543-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120045412-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885HDAC2 3/4885HDAC3 4/4885 |
| US-20100022543-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885HDAC2 3/4885HDAC3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.