Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 9/20 | 0.34 |
| ▸ | HTR2A | P28223 | 7/20 | 0.34 |
| ▸ | HTR2B | P41595 | 7/20 | 0.34 |
| ▸ | HTR1A | P08908 | 6/20 | 0.34 |
| ▸ | HTR1D | P28221 | 5/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19776272 | 0.90 | CHRNA7 (0.38) | CHRNA7MTNR1AMTNR1BNPC1ALDH1A1 | |
| SCHEMBL21468887 | 0.81 | CHRNA7 (0.43) | CHRNA7MTNR1AMTNR1BNPC1ALDH1A1 | |
| SCHEMBL19739924 | 0.77 | CHRNA7 (0.55) | CHRNA7MTNR1AMTNR1BNPC1ALDH1A1 | |
| SCHEMBL19756742 | 0.76 | CHRNA7 (0.42) | CHRNA7MTNR1AMTNR1BHTR2CHTR2A | |
| SCHEMBL19776276 | 0.76 | CD274 (0.37) | NPC1ALDH1A1RAB9AADRA2AADRA2C | |
| SCHEMBL19740288 | 0.76 | CHRNA7 (0.57) | CHRNA7MTNR1AMTNR1BNPC1ALDH1A1 | |
| SCHEMBL19756699 | 0.75 | CHRNA7 (0.44) | CHRNA7 | |
| SCHEMBL19756703 | 0.73 | CYP2A6 (0.37) | CHRNA7MTNR1AMTNR1BNPC1ALDH1A1 | |
| SCHEMBL21468888 | 0.72 | CHRNA7 (0.36) | CHRNA7MTNR1AMTNR1BALDH1A1HTR2C | |
| SCHEMBL1143507 | 0.71 | HTR2C (0.45) | MTNR1AMTNR1BHTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013776-A1 | TRICYCLIC HETEROARYL-SUBSTITUTED QUINOLINE AND AZAQUINOLINE COMPOUNDS AS PAR4 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | disclosed |
| US-20170369486-A1 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTONIC ACETYLCHOLINE RECEPTORS | AXOVANT SCIENCES GMBH (CH) | 2017-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369486-A1 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTONIC ACETYLCHOLINE RECEPTORS | CHRNA7, CHRNA6, CHRNA5 | CHRNA7 1/4885MTNR1A 640/4885MTNR1B 799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.