Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 20/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19760665 | 1.00 | ESR1 (0.78) | ESR1 | |
| SCHEMBL22002256 | 1.00 | ESR1 (0.78) | ESR1 | |
| SCHEMBL19760655 | 0.89 | ESR1 (0.80) | ESR1 | |
| SCHEMBL20912809 | 0.89 | ESR1 (0.80) | ESR1 | |
| SCHEMBL19760671 | 0.89 | ESR1 (0.80) | ESR1 | |
| SCHEMBL23186410 | 0.88 | ESR1 (1.00) | ESR1 | |
| SCHEMBL22213720 | 0.88 | ESR1 (1.00) | ESR1 | |
| SCHEMBL23783505 | 0.88 | ESR1 (1.00) | ESR1 | |
| SCHEMBL31412777 | 0.88 | ESR1 (1.00) | ESR1 | |
| SCHEMBL17839263 | 0.88 | ESR1 (1.00) | ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472162-B1 | HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2021-11-17 | — | — | EP | disclosed |
| US-10654867-B2 | Heteroaryl estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| US-20180002344-A1 | HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2018-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002344-A1 | HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ESR2, GPER1, ESRRA | ESR1 6/4885 |
| US-10654867-B2 | Heteroaryl estrogen receptor modulators and uses thereof | ESR2, GPER1, ESRRA | ESR1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.