⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19734247 | 0.92 | HRH3 (0.30) | — | |
| SCHEMBL19734248 | 0.90 | HRH3 (0.32) | — | |
| SCHEMBL14546271 | 0.86 | HRH3 (0.33) | — | |
| SCHEMBL22306023 | 0.82 | — | — | |
| SCHEMBL19756463 | 0.78 | — | — | |
| SCHEMBL19121846 | 0.78 | — | — | |
| SCHEMBL14252348 | 0.78 | — | — | |
| SCHEMBL19756472 | 0.78 | — | — | |
| SCHEMBL24734691 | 0.78 | HRH3 (0.33) | — | |
| SCHEMBL19727297 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030885-B2 | Substituted imidazo[2,1-f][1,2,4]triazines as PI3K-gamma inhibitors | INCYTE CORPORATION (US) | 2024-07-09 | — | — | US | disclosed |
| US-20180009816-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS | INCYTE CORPORATION | 2018-01-11 | — | — | US | disclosed |