Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 18/20 | 0.73 |
| ▸ | DLK1 | P80370 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16220346 | 0.84 | MAP3K12 (1.00) | MAP3K12DLK1 | |
| SCHEMBL22239459 | 0.80 | MAP3K12 (0.74) | MAP3K12DLK1MAPK1SYK | |
| SCHEMBL16220347 | 0.80 | MAP3K12 (0.91) | MAP3K12DLK1SYK | |
| SCHEMBL16220349 | 0.79 | MAP3K12 (0.90) | MAP3K12 | |
| SCHEMBL16220122 | 0.77 | MAP3K12 (1.00) | MAP3K12 | |
| SCHEMBL19771662 | 0.77 | MAP3K12 (0.52) | MAP3K12SYK | |
| SCHEMBL16220124 | 0.76 | MAP3K12 (0.98) | MAP3K12 | |
| SCHEMBL16220029 | 0.76 | MAP3K12 (0.79) | MAP3K12 | |
| SCHEMBL16220253 | 0.76 | MAP3K12 (0.91) | MAP3K12 | |
| SCHEMBL16220129 | 0.76 | MAP3K12 (0.84) | MAP3K12DLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9868720-B2 | C-linked heterocycloaklyl substituted pyrimidines and their uses | GENENTECH, INC. (US) | 2018-01-16 | — | — | US | disclosed |