Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 18/20 | 0.69 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19771904 | 1.00 | PDE2A (0.69) | PDE2AIDO1CYP3A4CYP3A5 | |
| SCHEMBL22389476 | 0.85 | PDE2A (0.54) | PDE2AIDO1 | |
| SCHEMBL22389494 | 0.85 | PDE2A (0.54) | PDE2AIDO1 | |
| SCHEMBL84521 | 0.82 | PDE2A (0.70) | PDE2AIDO1CYP3A4CYP3A5 | |
| SCHEMBL1035450 | 0.81 | PDE2A (1.00) | PDE2A | |
| SCHEMBL20811535 | 0.80 | PDE2A (0.67) | PDE2AIDO1 | |
| SCHEMBL22221342 | 0.80 | PDE2A (0.67) | PDE2AIDO1 | |
| SCHEMBL20811529 | 0.80 | PDE2A (0.67) | PDE2AIDO1 | |
| SCHEMBL18103269 | 0.79 | PDE2A (0.66) | PDE2AIDO1CYP3A4CYP3A5 | |
| SCHEMBL3315570 | 0.79 | PDE2A (0.66) | PDE2AIDO1CYP3A4CYP3A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9868748-B2 | Thiazolopyrrolidine inhibitors of ROR- γ | VITAE PHARMACEUTICALS, INC. (US) | 2018-01-16 | — | — | US | disclosed |