Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL12 | P48061 | 2/20 | 0.65 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22065125 | 0.96 | CXCL12 (0.66) | CXCL12RIPK1KDM4ECDC7PIM1 | |
| SCHEMBL19782907 | 0.86 | CXCL12 (0.69) | CXCL12RIPK1KDM4ECDC7PIM1 | |
| SCHEMBL22065921 | 0.84 | CXCL12 (0.66) | CXCL12RIPK1KDM4ECDC7PIM1 | |
| SCHEMBL19782686 | 0.83 | CXCL12 (0.91) | CXCL12RIPK1KDM4ECDC7PIM1 | |
| SCHEMBL22065927 | 0.83 | CXCL12 (0.68) | CXCL12RIPK1KDM4ECDC7PIM1 | |
| SCHEMBL19782909 | 0.83 | CXCL12 (0.65) | CXCL12RIPK1KDM4ECDC7PIM1 | |
| SCHEMBL19783006 | 0.83 | CXCL12 (0.73) | CXCL12RIPK1KDM4ECDC7PIM1 | |
| SCHEMBL19782836 | 0.82 | CXCL12 (0.69) | CXCL12RIPK1KDM4ECDC7PIM1 | |
| SCHEMBL19782681 | 0.81 | CXCL12 (0.71) | CXCL12RIPK1KDM4ECDC7PIM1 | |
| SCHEMBL19782800 | 0.81 | CXCL12 (0.71) | CXCL12RIPK1KDM4ECDC7PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018011376-A1 | PYRIMIDINONE DERIVATIVES AND USES THEREOF TO NEUTRALIZE THE BIOLOGICAL ACTIVITY OF CHEMOKINES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - (FR) | 2018-01-18 | — | — | WO | disclosed |