SCHEMBL19783754

SCHEMBL19783754

COc1cnc2c(-c3nc4cc(F)c(O[C@@H](C)[C@@H](C)OC(=O)Nc5cnc(OC[C@@H](C)O[Si](C)(C)C(C)(C)C)nc5)cc4s3)cc(Cl)cc2c1

nearest known ligand 0.57

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 20/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21395785 1.00 F2RL3 (0.57) F2RL3
SCHEMBL31114059 1.00 F2RL3 (0.57) F2RL3
SCHEMBL31113803 0.90 F2RL3 (0.62) F2RL3
SCHEMBL19783731 0.90 F2RL3 (0.62) F2RL3
SCHEMBL31113578 0.90 F2RL3 (0.62) F2RL3
SCHEMBL19783515 0.90 F2RL3 (0.62) F2RL3
SCHEMBL31113496 0.88 F2RL3 (0.73) F2RL3
SCHEMBL21395897 0.88 F2RL3 (0.73) F2RL3
SCHEMBL31113763 0.86 F2RL3 (0.72) F2RL3
SCHEMBL19783620 0.86 F2RL3 (0.72) F2RL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018013774-A1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-01-18 WO disclosed