Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19784039 | 1.00 | MAPT (0.38) | MAPTTHRBCMA1ALDH1A1TSHR | |
| SCHEMBL18313012 | 0.89 | KDM4E (0.41) | MAPTTHRBCMA1ALDH1A1TSHR | |
| SCHEMBL22331617 | 0.89 | KDM4E (0.41) | MAPTTHRBCMA1ALDH1A1TSHR | |
| SCHEMBL19783916 | 0.88 | EPHA2 (0.45) | ALDH1A1KDM4EHPGDKMT2ALMNA | |
| SCHEMBL19783918 | 0.88 | EPHA2 (0.45) | ALDH1A1KDM4EHPGDKMT2ALMNA | |
| SCHEMBL19784029 | 0.86 | MAPT (0.41) | MAPTTHRBALDH1A1TSHRKDM4E | |
| SCHEMBL19784027 | 0.83 | KMT2A (0.42) | MAPTTHRBALDH1A1TSHRKDM4E | |
| SCHEMBL22590987 | 0.83 | GSK3B (0.34) | ALDH1A1TSHRKDM4EHPGDKMT2A | |
| SCHEMBL21238078 | 0.83 | GSK3B (0.34) | ALDH1A1TSHRKDM4EHPGDKMT2A | |
| SCHEMBL19783952 | 0.83 | GSK3B (0.34) | ALDH1A1TSHRKDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481823-B1 | 7-SUBSTITUTED 1-PYRIDYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | Bayer Pharma AG (DE) | 2020-10-28 | — | — | EP | disclosed |
| WO-2018011017-A1 | 7-SUBSTITUTED 1-PYRIDYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-01-18 | — | — | WO | disclosed |