Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.50 |
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CD38 | P28907 | 2/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16973827 | 0.87 | SMYD3 (0.49) | CNR1GRM5CD38SMYD3 | |
| SCHEMBL16973834 | 0.84 | SMYD3 (0.46) | GRM5CD38SMYD3 | |
| SCHEMBL30040519 | 0.83 | CD38 (0.63) | CNR1GRM5CD38SMYD3 | |
| SCHEMBL16973688 | 0.83 | CD38 (0.42) | CNR1GRM5CD38SMYD3 | |
| SCHEMBL16984511 | 0.83 | GRM5 (0.46) | CNR1GRM5CD38 | |
| Hydrochloric Acid SCHEMBL16973644 | 0.82 | GRM5 (0.45) | CNR1GRM5CD38 | |
| SCHEMBL22829189 | 0.82 | GRM5 (0.45) | CNR1GRM5CD38SMYD3 | |
| SCHEMBL22829190 | 0.82 | GRM5 (0.45) | CNR1GRM5CD38SMYD3 | |
| SCHEMBL16973824 | 0.80 | GRM5 (0.43) | CNR1GRM5CD38SMYD3 | |
| Trifluoroacetic Acid SCHEMBL16973775 | 0.79 | CDK2 (0.49) | CNR1GRM5CD38SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484879-B1 | HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARM SPA (IT) | 2020-12-30 | — | — | EP | disclosed |
| WO-2018081276-A1 | COMPOUNDS | TESARO, INC. (US) | 2018-05-03 | — | — | WO | disclosed |
| WO-2018011090-A1 | HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-01-18 | — | — | WO | disclosed |