SCHEMBL19784764

SCHEMBL19784764

COc1cnc2c(-c3nc4cc(F)c(OC5CCCC[C@H]5OC(=O)Nc5cnc(C)nc5)cc4s3)cc(C)cc2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19784765 1.00 F2RL3 (1.00) F2RL3
SCHEMBL19784728 0.99 F2RL3 (1.00) F2RL3
SCHEMBL21424318 0.99 F2RL3 (1.00) F2RL3
SCHEMBL19784687 0.97 F2RL3 (1.00) F2RL3
SCHEMBL21424381 0.97 F2RL3 (1.00) F2RL3
SCHEMBL19784688 0.97 F2RL3 (1.00) F2RL3
SCHEMBL19784525 0.94 F2RL3 (1.00) F2RL3
SCHEMBL21941522 0.94 F2RL3 (1.00) F2RL3
SCHEMBL19784654 0.94 F2RL3 (1.00) F2RL3
SCHEMBL21407918 0.93 F2RL3 (0.90) F2RL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3484881-B1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2020-04-29 EP disclosed
WO-2018013770-A1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-01-18 WO disclosed