Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785043 | 0.91 | PTPN11 (1.00) | PTPN11KCNH2MAPK3MAPK1EGFR | |
| SCHEMBL30296025 | 0.91 | PTPN11 (1.00) | PTPN11KCNH2MAPK3MAPK1EGFR | |
| SCHEMBL26041993 | 0.89 | PTPN11 (0.78) | PTPN11KCNH2MAPK3MAPK1EGFR | |
| SCHEMBL20399757 | 0.85 | PTPN11 (0.73) | PTPN11KCNH2MAPK3MAPK1EGFR | |
| SCHEMBL24689449 | 0.83 | PTPN11 (0.64) | PTPN11KCNH2EGFR | |
| SCHEMBL24233652 | 0.82 | PTPN11 (0.81) | PTPN11KCNH2MAPK3MAPK1EGFR | |
| SCHEMBL21154389 | 0.82 | PTPN11 (0.85) | PTPN11KCNH2MAPK3MAPK1EGFR | |
| SCHEMBL25514319 | 0.82 | PTPN11 (0.84) | PTPN11KCNH2MAPK3MAPK1EGFR | |
| SCHEMBL23083699 | 0.82 | PTPN11 (0.83) | PTPN11KCNH2MAPK3MAPK1EGFR | |
| SCHEMBL28912086 | 0.81 | PTPN11 (0.67) | PTPN11KCNH2MAPK3MAPK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013597-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |