Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 15/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785447 | 0.84 | PTPN11 (0.43) | PTPN11EGFRKCNH2PIK3CAMTOR | |
| SCHEMBL19785344 | 0.81 | PTPN11 (0.43) | PTPN11KCNH2 | |
| SCHEMBL23083948 | 0.80 | PTPN11 (0.56) | PTPN11EGFRKCNH2 | |
| SCHEMBL25514532 | 0.80 | PTPN11 (0.61) | PTPN11EGFRKCNH2 | |
| SCHEMBL21154552 | 0.78 | PTPN11 (0.73) | PTPN11EGFRKCNH2 | |
| SCHEMBL25514538 | 0.78 | PTPN11 (0.49) | PTPN11EGFRKCNH2SCN10A | |
| SCHEMBL23083594 | 0.77 | PTPN11 (0.53) | PTPN11EGFRKCNH2 | |
| SCHEMBL21154789 | 0.77 | PTPN11 (0.57) | PTPN11EGFRKCNH2 | |
| SCHEMBL21154161 | 0.77 | PTPN11 (0.60) | PTPN11EGFRKCNH2 | |
| SCHEMBL22789668 | 0.77 | PTPN11 (0.50) | PTPN11EGFRKCNH2SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484856-B1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2018013597-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |