Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785479 | 0.91 | PTPN11 (0.80) | PTPN11KCNH2 | |
| SCHEMBL19785110 | 0.85 | PTPN11 (0.80) | PTPN11 | |
| SCHEMBL19785227 | 0.84 | PTPN11 (0.81) | PTPN11KCNH2 | |
| SCHEMBL19785229 | 0.84 | PTPN11 (0.84) | PTPN11KCNH2 | |
| SCHEMBL30511929 | 0.84 | PTPN11 (0.84) | PTPN11KCNH2 | |
| SCHEMBL25514142 | 0.83 | PTPN11 (0.65) | PTPN11 | |
| SCHEMBL16914407 | 0.81 | PTPN11 (1.00) | PTPN11KCNH2 | |
| SCHEMBL16914264 | 0.80 | PTPN11 (1.00) | PTPN11 | |
| SCHEMBL19785225 | 0.79 | PTPN11 (0.78) | PTPN11KCNH2 | |
| SCHEMBL23186805 | 0.79 | PTPN11 (0.69) | PTPN11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013597-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |