Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20388764 | 0.91 | PTPN11 (0.73) | PTPN11 | |
| SCHEMBL19785462 | 0.90 | PTPN11 (0.59) | PTPN11 | |
| SCHEMBL25514243 | 0.90 | PTPN11 (0.68) | PTPN11 | |
| SCHEMBL21154758 | 0.89 | PTPN11 (0.61) | PTPN11 | |
| SCHEMBL30295897 | 0.89 | PTPN11 (0.70) | PTPN11 | |
| SCHEMBL19785317 | 0.89 | PTPN11 (0.70) | PTPN11 | |
| SCHEMBL28502424 | 0.88 | PTPN11 (0.62) | PTPN11 | |
| SCHEMBL19785330 | 0.88 | PTPN11 (0.61) | PTPN11 | |
| SCHEMBL21154439 | 0.88 | PTPN11 (0.59) | PTPN11 | |
| SCHEMBL25514249 | 0.87 | PTPN11 (0.74) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484856-B1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2018013597-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |