Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24233618 | 0.85 | PTPN11 (0.50) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL19785514 | 0.84 | PTPN11 (0.60) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL19785431 | 0.84 | PTPN11 (0.57) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL20388767 | 0.84 | PTPN11 (0.76) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL19785531 | 0.83 | PTPN11 (0.76) | PTPN11KCNH2 | |
| SCHEMBL25514335 | 0.83 | PTPN11 (0.60) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL16925395 | 0.81 | PTPN11 (0.76) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL19785430 | 0.81 | PTPN11 (0.54) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL19785432 | 0.78 | PTPN11 (0.55) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL19651498 | 0.77 | PTPN11 (0.55) | PTPN11KCNH2MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484856-B1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2018013597-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |