Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.53 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978958 | 0.90 | BACE1 (0.48) | BACE1BACE2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1978188 | 0.86 | BACE1 (0.55) | BACE1BACE2CYP2D6CTSD | |
| SCHEMBL1978595 | 0.84 | BACE1 (0.60) | BACE1BACE2CTSD | |
| SCHEMBL1979859 | 0.83 | BACE1 (0.61) | BACE1BACE2CYP2D6CTSD | |
| SCHEMBL1980140 | 0.83 | BACE1 (0.61) | BACE1BACE2CYP2D6 | |
| SCHEMBL1979164 | 0.82 | BACE1 (0.59) | BACE1BACE2CTSD | |
| SCHEMBL1978950 | 0.81 | BACE1 (0.61) | BACE1BACE2 | |
| SCHEMBL1977436 | 0.79 | BACE1 (0.55) | BACE1BACE2CYP2D6 | |
| SCHEMBL1979294 | 0.78 | BACE1 (0.53) | BACE1BACE2 | |
| SCHEMBL1980029 | 0.76 | BACE1 (0.51) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070029-A1 | AMINO OXAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | claimed |
| WO-2011070029-A1 | AMINO OXAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |