Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21069145 | 0.93 | PSEN1 (0.45) | CHRM4CHRM2SMARCA2SMARCA4PSEN1 | |
| SCHEMBL21374488 | 0.93 | PSEN1 (0.45) | CHRM4CHRM2SMARCA2SMARCA4PSEN1 | |
| SCHEMBL21050448 | 0.93 | PSEN1 (0.45) | CHRM4CHRM2SMARCA2SMARCA4PSEN1 | |
| SCHEMBL21050446 | 0.93 | PSEN1 (0.45) | CHRM4CHRM2SMARCA2SMARCA4PSEN1 | |
| SCHEMBL21050443 | 0.93 | PSEN1 (0.45) | CHRM4CHRM2SMARCA2SMARCA4PSEN1 | |
| SCHEMBL24083325 | 0.93 | PSEN1 (0.45) | CHRM4CHRM2SMARCA2SMARCA4PSEN1 | |
| SCHEMBL16685020 | 0.86 | CHRM4 (0.47) | CHRM4CHRM2SMARCA2SMARCA4PSEN1 | |
| Hydrochloric Acid SCHEMBL17077952 | 0.85 | CHRM4 (0.47) | CHRM4CHRM2SMARCA2SMARCA4PSEN1 | |
| SCHEMBL31614725 | 0.80 | CHRM4 (0.47) | CHRM4CHRM2SMARCA2SMARCA4PSEN1 | |
| SCHEMBL20159687 | 0.80 | NR1H2 (0.41) | CHRM4CHRM2SMARCA2SMARCA4PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484884-B1 | FUSED PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |
| WO-2018011164-A1 | FUSED PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-18 | — | — | WO | disclosed |