Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 15/20 | 0.91 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.76 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.76 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.76 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.76 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.76 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21093524 | 0.95 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050408 | 0.95 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050407 | 0.95 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050406 | 0.95 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050352 | 0.87 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21093525 | 0.87 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050354 | 0.87 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050353 | 0.87 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19787661 | 0.85 | APP (0.91) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050395 | 0.85 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018011164-A1 | FUSED PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-18 | — | — | WO | disclosed |