Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | STK3 | Q13188 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.31 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.31 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9939369 | 0.87 | ATR (0.46) | ATRP2RX3MAPKAPK2GSK3B | |
| SCHEMBL9649 | 0.79 | KDM4E (0.38) | KMT2AMEN1 | |
| SCHEMBL3708385 | 0.75 | KCNQ3 (0.33) | MAPKAPK2CHEK1AURKACDK2FLT4 | |
| SCHEMBL24337509 | 0.73 | ATR (0.33) | ATRKMT2AP2RX3 | |
| SCHEMBL19250103 | 0.73 | ATR (0.41) | ATRP2RX3MAPKAPK2GSK3B | |
| SCHEMBL26441879 | 0.73 | DPP4 (0.40) | ATRP2RX3DPP4 | |
| SCHEMBL26089115 | 0.72 | ATR (0.40) | ATRP2RX3MAPKAPK2GAA | |
| SCHEMBL13659734 | 0.72 | ATR (0.41) | ATRP2RX3MAPKAPK2 | |
| SCHEMBL8342499 | 0.72 | ATR (0.41) | ATRKMT2AGSK3BGAAMEN1 | |
| SCHEMBL16712898 | 0.70 | ATR (0.42) | ATRP2RX3MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022006550-A1 | 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES | REMIX THERAPEUTICS INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| US-RE47334-E1 | Macrocyclic inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2019-04-02 | — | — | US | disclosed |
| US-9873716-B2 | Macrocyclic inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2018-01-23 | — | — | US | disclosed |