Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | TP53 | P04637 | 4/20 | 0.60 |
| ▸ | BRD4 | O60885 | 2/20 | 0.59 |
| ▸ | BRD2 | P25440 | 1/20 | 0.59 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.59 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1137531 | 0.87 | BRD4 (0.70) | MAPTTP53BRD4BRD2BRD3 | |
| SCHEMBL2621620 | 0.86 | CNR1 (0.60) | MAPTBRD4BRD2BRD3BRDT | |
| SCHEMBL6524399 | 0.86 | VEGFA (0.65) | MAPTTP53BRD4BRD2BRD3 | |
| Hydrochloric Acid SCHEMBL11454825 | 0.86 | BRD4 (0.68) | MAPTTP53BRD4BRD2BRD3 | |
| SCHEMBL4993019 | 0.85 | BRD4 (0.59) | MAPTTP53BRD4BRD2BRD3 | |
| SCHEMBL4992892 | 0.85 | BRD4 (0.68) | MAPTTP53BRD4BRD2BRD3 | |
| SCHEMBL4437360 | 0.85 | BRD4 (0.56) | MAPTTP53BRD4BRD2BRD3 | |
| SCHEMBL17477640 | 0.84 | MAPT (0.63) | MAPTTP53BRD4BRD2BRD3 | |
| SCHEMBL4992841 | 0.84 | BRD4 (0.56) | MAPTTP53BRD4BRD2BRD3 | |
| Hydrochloric Acid SCHEMBL11540853 | 0.84 | MAPT (0.44) | MAPTTP53BRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |