Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 11/20 | 0.58 |
| ▸ | ACE | P12821 | 3/20 | 0.58 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
| ▸ | TPH1 | P17752 | 2/20 | 0.40 |
| ▸ | TPH2 | Q8IWU9 | 2/20 | 0.40 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20681824 | 1.00 | MME (0.58) | MMEACEMMEL1TAAR1GPR88 | |
| SCHEMBL11969672 | 0.91 | MME (0.69) | MMEACEMMEL1TAAR1TPH1 | |
| SCHEMBL18800933 | 0.91 | MME (0.69) | MMEACEMMEL1TAAR1TPH1 | |
| SCHEMBL19605644 | 0.87 | MME (0.52) | MMEACEMMEL1TAAR1 | |
| SCHEMBL20376145 | 0.87 | MME (0.52) | MMEACEMMEL1TAAR1 | |
| SCHEMBL21310252 | 0.83 | MME (0.85) | MMEACEMMEL1 | |
| SCHEMBL18922283 | 0.82 | MME (0.57) | MMEACEGPR88 | |
| SCHEMBL19688037 | 0.82 | MME (0.57) | MMEACEGPR88 | |
| SCHEMBL21350789 | 0.80 | MME (0.51) | MMEACEMMEL1TAAR1TPH1 | |
| SCHEMBL19687852 | 0.80 | MME (0.45) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873685-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-01-23 | — | — | US | disclosed |