Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA2 | Q15349 | 13/20 | 0.68 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.63 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979620 | 0.81 | RPS6KA2 (1.00) | RPS6KA2MAPKAPK2RPS6KA3 | |
| SCHEMBL1979125 | 0.78 | RPS6KA2 (0.68) | RPS6KA2MAPKAPK2RPS6KA3CLK1GSK3B | |
| SCHEMBL12598642 | 0.75 | RPS6KA2 (1.00) | RPS6KA2RPS6KA3 | |
| SCHEMBL1979131 | 0.72 | RPS6KA2 (0.81) | RPS6KA2MAPKAPK2RPS6KA3 | |
| SCHEMBL12598632 | 0.72 | RPS6KA2 (0.73) | RPS6KA2MAPKAPK2RPS6KA3 | |
| SCHEMBL12598636 | 0.72 | RPS6KA2 (0.71) | RPS6KA2RPS6KA3 | |
| SCHEMBL3078970 | 0.71 | RPS6KA2 (0.66) | RPS6KA2MAPKAPK2RPS6KA3 | |
| SCHEMBL3079464 | 0.71 | RPS6KA3 (1.00) | RPS6KA2MAPKAPK2RPS6KA3 | |
| SCHEMBL1978707 | 0.70 | RPS6KA2 (0.74) | RPS6KA2MAPKAPK2RPS6KA3 | |
| SCHEMBL1978106 | 0.70 | RPS6KA2 (0.64) | RPS6KA2MAPKAPK2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509980-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | Boehringer Ingelheim International GmbH (DE) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011071716-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-16 | — | — | WO | disclosed |