Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL619674 | 0.94 | KDM4E (0.64) | KDM4EATMHTTCA1CA2 | |
| SCHEMBL1829468 | 0.94 | KDM4E (0.68) | KDM4EATMHTTCA1CA2 | |
| SCHEMBL1821870 | 0.92 | KDM4E (0.69) | KDM4EATMHTTCA1CA2 | |
| SCHEMBL1828856 | 0.92 | KDM4E (0.69) | KDM4EATMHTTCA1CA2 | |
| SCHEMBL1822388 | 0.91 | KDM4E (0.54) | KDM4EATMHTTCA1CA2 | |
| SCHEMBL1819491 | 0.91 | KDM4E (0.54) | KDM4EATMHTTCA1CA2 | |
| SCHEMBL7958276 | 0.90 | KDM4E (0.50) | KDM4EATMHTTCA1CA2 | |
| SCHEMBL10265984 | 0.90 | KDM4E (0.52) | KDM4EATMHTTCA1CA2 | |
| SCHEMBL1268666 | 0.90 | HDAC3 (0.60) | KDM4EATMHTTCA1CA2 | |
| Hydrochloric Acid SCHEMBL309162 | 0.88 | HDAC3 (0.59) | KDM4EATMHTTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |