Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 14/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980257 | 0.89 | PIM1 (0.52) | PIM1TLR8TLR7PIM3PIM2 | |
| SCHEMBL12597452 | 0.86 | PIM1 (0.49) | PIM1TLR8TLR7PIM3PIM2 | |
| SCHEMBL1981546 | 0.85 | PIM1 (0.44) | PIM1TLR8TLR7PIM3PIM2 | |
| SCHEMBL1981037 | 0.84 | PIM1 (0.57) | PIM1TLR8TLR7PIM3PIM2 | |
| SCHEMBL1981919 | 0.84 | PIM1 (0.47) | PIM1TLR8TLR7PIM3PIM2 | |
| SCHEMBL12597448 | 0.83 | PIM1 (0.46) | PIM1MAPTTLR8TLR7PIM3 | |
| SCHEMBL1979797 | 0.82 | PIM1 (0.47) | PIM1TLR8TLR7PIM3PIM2 | |
| SCHEMBL1978448 | 0.82 | PIM1 (0.45) | PIM1TLR8TLR7PIM3PIM2 | |
| SCHEMBL1980501 | 0.82 | PIM1 (0.45) | PIM1TLR8TLR7PIM3PIM2 | |
| SCHEMBL1978983 | 0.82 | PIM1 (0.41) | PIM1TLR8TLR7PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |