Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 7/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979797 | 0.86 | PIM1 (0.47) | PIM1PIM2PIM3BRD4BRD2 | |
| SCHEMBL1980607 | 0.86 | IDO1 (0.47) | PIM1PIM2PIM3NR3C1BRD4 | |
| SCHEMBL12597839 | 0.85 | FYN (0.44) | PIM1PIM2PIM3NR3C1BRD4 | |
| SCHEMBL12597833 | 0.84 | PIM1 (0.45) | PIM1PIM2PIM3BRD4BRD2 | |
| SCHEMBL1980257 | 0.83 | PIM1 (0.52) | PIM1PIM2PIM3BRD4BRD2 | |
| SCHEMBL1561346 | 0.81 | PIM1 (0.50) | SLC22A12PIM1CKS1BSKP2PIM2 | |
| SCHEMBL12597831 | 0.81 | PIM1 (0.43) | PIM1PIM2PIM3BRD4BRD2 | |
| SCHEMBL1982206 | 0.81 | NEK1 (0.42) | PIM1PIM2PIM3 | |
| SCHEMBL12597452 | 0.80 | PIM1 (0.49) | PIM1PIM2PIM3BRD4BRD2 | |
| SCHEMBL1979534 | 0.80 | PIM1 (0.43) | PIM1PIM2PIM3BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |