Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1980443 | 0.99 | BACE1 (0.70) | BACE1BACE2 | |
| SCHEMBL1979498 | 0.92 | BACE1 (0.69) | BACE1BACE2 | |
| SCHEMBL1981852 | 0.89 | BACE1 (0.69) | BACE1BACE2 | |
| SCHEMBL1972910 | 0.88 | BACE1 (0.77) | BACE1BACE2 | |
| SCHEMBL1980916 | 0.88 | BACE1 (0.67) | BACE1BACE2 | |
| Hydrochloric Acid SCHEMBL1973806 | 0.88 | BACE1 (0.76) | BACE1BACE2 | |
| SCHEMBL1984741 | 0.87 | BACE1 (0.68) | BACE1BACE2 | |
| SCHEMBL1973395 | 0.83 | BACE1 (1.00) | BACE1BACE2 | |
| SCHEMBL1975259 | 0.83 | BACE1 (1.00) | BACE1BACE2 | |
| SCHEMBL1979047 | 0.83 | BACE1 (0.67) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011069934-A1 | 2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | claimed |
| WO-2011069934-A1 | 2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |