Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.53 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1977793 | 0.90 | BACE1 (0.57) | BACE1BACE2CYP2D6 | |
| SCHEMBL1979402 | 0.89 | BACE1 (0.67) | BACE1BACE2 | |
| SCHEMBL1983963 | 0.87 | BACE1 (0.57) | BACE1BACE2GRM4CYP2D6 | |
| SCHEMBL1979071 | 0.85 | BACE1 (0.47) | BACE1BACE2CYP2D6 | |
| SCHEMBL1978259 | 0.85 | BACE1 (0.62) | BACE1BACE2GRM4 | |
| SCHEMBL1976789 | 0.82 | BACE1 (0.69) | BACE1BACE2CYP2D6 | |
| SCHEMBL1979257 | 0.81 | BACE1 (0.65) | BACE1BACE2 | |
| SCHEMBL1979437 | 0.81 | BACE1 (0.61) | BACE1BACE2CYP2D6 | |
| SCHEMBL1978992 | 0.81 | BACE1 (0.65) | BACE1BACE2 | |
| SCHEMBL1977847 | 0.80 | BACE1 (0.55) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070029-A1 | AMINO OXAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | claimed |
| WO-2011070029-A1 | AMINO OXAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |