Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 9/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979605 | 0.85 | BACE1 (0.32) | BACE1BACE2CTSDNR1H2 | |
| SCHEMBL1978652 | 0.85 | SIRT2 (0.38) | BACE1BACE2 | |
| SCHEMBL1980686 | 0.81 | BACE1 (0.34) | BACE1BACE2CTSD | |
| SCHEMBL15264586 | 0.78 | BACE1 (0.47) | BACE1 | |
| SCHEMBL15264589 | 0.78 | BACE1 (0.47) | BACE1 | |
| SCHEMBL1977402 | 0.78 | BACE1 (0.48) | BACE1BACE2 | |
| SCHEMBL1977399 | 0.78 | BACE1 (0.48) | BACE1BACE2 | |
| SCHEMBL15264718 | 0.77 | BACE1 (0.50) | BACE1BACE2CTSD | |
| SCHEMBL15265026 | 0.77 | BACE1 (0.50) | BACE1BACE2CTSD | |
| SCHEMBL15263657 | 0.77 | BACE1 (0.50) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509966-A1 | AMINO OXAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011070029-A1 | AMINO OXAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |