Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.46 |
| ▸ | F13A1 | P00488 | 2/20 | 0.44 |
| ▸ | TGM1 | P22735 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980743 | 1.00 | MEN1 (0.56) | MEN1KMT2ANPY5RVCAM1F13A1 | |
| SCHEMBL16372574 | 0.86 | MEN1 (0.48) | MEN1KMT2ANPY5RVCAM1F13A1 | |
| SCHEMBL15570021 | 0.84 | MEN1 (0.53) | MEN1KMT2ATHRBCA1CA2 | |
| SCHEMBL15570023 | 0.84 | MEN1 (0.53) | MEN1KMT2ATHRBCA1CA2 | |
| SCHEMBL1955471 | 0.82 | KMT2A (0.59) | MEN1KMT2AVCAM1F13A1TGM1 | |
| SCHEMBL1955468 | 0.82 | KMT2A (0.59) | MEN1KMT2AVCAM1F13A1TGM1 | |
| SCHEMBL1652853 | 0.82 | KMT2A (0.61) | MEN1KMT2AVCAM1F13A1TGM1 | |
| SCHEMBL27816041 | 0.80 | KMT2A (0.63) | MEN1KMT2AVCAM1THRBCA1 | |
| SCHEMBL7007042 | 0.80 | NPY5R (0.67) | MEN1KMT2ANPY5RF13A1TGM1 | |
| SCHEMBL1983511 | 0.80 | NPY5R (0.67) | MEN1KMT2ANPY5RF13A1TGM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331554-B1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | JANSSEN R & D IRELAND (IE) | 2013-03-06 | — | — | EP | disclosed |
| US-8357687-B2 | Macrocyclic indole derivatives useful as hepatitis C virus inhibitors | TIBOTEC PHARMACEUTICALS (IE) | 2013-01-22 | — | — | US | disclosed |
| US-20110152279-A1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS (IE) | 2011-06-23 | — | — | US | disclosed |
| WO-2010018233-A1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS (IE) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152279-A1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | IDO1, IDO2, ZC3HAV1 | MEN1 3151/4885KMT2A 2256/4885NPY5R 356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.