Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 1.00 |
| ▸ | RET | P07949 | 5/20 | 1.00 |
| ▸ | FLT3 | P36888 | 5/20 | 1.00 |
| ▸ | CDK7 | P50613 | 4/20 | 1.00 |
| ▸ | AURKB | Q96GD4 | 4/20 | 1.00 |
| ▸ | KDR | P35968 | 4/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 3/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 3/20 | 1.00 |
| ▸ | LTK | P29376 | 3/20 | 1.00 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 1.00 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 1.00 |
| ▸ | MST1R | Q04912 | 3/20 | 1.00 |
| ▸ | NTRK3 | Q16288 | 3/20 | 1.00 |
| ▸ | NTRK2 | Q16620 | 3/20 | 1.00 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 1.00 |
| ▸ | ALK | Q9UM73 | 3/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 3/20 | 1.00 |
| ▸ | ABL1 | P00519 | 2/20 | 1.00 |
| ▸ | DAPK3 | O43293 | 2/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14448886 | 1.00 | NTRK1 (1.00) | NTRK1RETFLT3CDK7AURKB | |
| SCHEMBL1980864 | 1.00 | NTRK1 (1.00) | NTRK1RETFLT3CDK7AURKB | |
| SCHEMBL5476209 | 0.84 | FLT3 (0.73) | NTRK1RETFLT3CDK7AURKB | |
| SCHEMBL14448917 | 0.84 | LRRK2 (0.73) | NTRK1RETFLT3CDK7AURKB | |
| SCHEMBL14448936 | 0.84 | NTRK1 (0.73) | NTRK1RETFLT3CDK7AURKB | |
| SCHEMBL5473156 | 0.84 | NTRK1 (0.73) | NTRK1RETFLT3CDK7AURKB | |
| SCHEMBL5465281 | 0.84 | NTRK1 (0.73) | NTRK1RETFLT3CDK7AURKB | |
| SCHEMBL5464546 | 0.84 | LRRK2 (0.73) | NTRK1RETFLT3CDK7AURKB | |
| SCHEMBL8468388 | 0.84 | NTRK1 (0.73) | NTRK1RETFLT3CDK7AURKB | |
| SCHEMBL5472578 | 0.84 | NTRK1 (0.73) | NTRK1RETFLT3CDK7AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130344165-A1 | JAB1 INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-12-26 | — | — | US | claimed |
| WO-2012116137-A2 | JAB1 BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2012-08-30 | — | — | WO | claimed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | claimed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | claimed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | claimed |
| US-20030108946-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2003-06-12 | — | — | US | claimed |
| EP-1247803-A2 | Indolinone compounds suitable for modulation of protein kinases | Sugen, Inc. (US) | 2002-10-09 | — | — | EP | claimed |
| US-20020022626-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | TANG PENG CHO (US) | 2002-02-21 | — | — | US | claimed |
| EP-0929520-A1 | INDOLINONE COMBINATORIAL LIBRARIES AND RELATED PRODUCTS AND METHODS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1999-07-21 | — | — | EP | claimed |
| WO-1998007695-A1 | INDOLINONE COMBINATORIAL LIBRARIES AND RELATED PRODUCTS AND METHODS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1998-02-26 | — | — | WO | claimed |
| US-12377194-B2 | JAB1 inhibitory compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2025-08-05 | — | — | US | disclosed |
| US-20220023506-A1 | JAB1 Inhibitory Compositions for Ossification and Methods Related Thereto | EMORY UNIVERSITY | 2022-01-27 | — | — | US | disclosed |
| US-11179500-B2 | JAB1 inhibitory compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2021-11-23 | — | — | US | disclosed |
| US-20130344165-A1 | JAB1 INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-12-26 | — | — | US | disclosed |
| WO-2012116137-A2 | JAB1 BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2012-08-30 | — | — | WO | disclosed |
| US-6147106-A | USEFUL FOR THE TREATMENT OF DISEASES RELATED TO UNREGULATED PROTEIN KINASE SIGNAL TRANSDUCTION, INCLUDING CELL PROLIFERATIVE DISEASES SUCH AS CANCER, ATHEROSCLEROSIS, ARTHRITIS AND RESTENOSIS AND METABOLIC DISEASES SUCH AS | SUGEN, INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0929520-A1 | INDOLINONE COMBINATORIAL LIBRARIES AND RELATED PRODUCTS AND METHODS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1999-07-21 | — | — | EP | disclosed |
| EP-0929520-A1 | INDOLINONE COMBINATORIAL LIBRARIES AND RELATED PRODUCTS AND METHODS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998007695-A1 | INDOLINONE COMBINATORIAL LIBRARIES AND RELATED PRODUCTS AND METHODS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1998-02-26 | — | — | WO | disclosed |
| WO-1998007695-A1 | INDOLINONE COMBINATORIAL LIBRARIES AND RELATED PRODUCTS AND METHODS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1998-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020022626-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | NTRK1 248/4885RET 286/4885FLT3 370/4885 |
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | NTRK1 175/4885RET 3720/4885FLT3 4311/4885 |
| US-20030108946-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | NTRK1 248/4885RET 286/4885FLT3 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.