Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.61 |
| ▸ | F9 | P00740 | 19/20 | 0.48 |
| ▸ | F10 | P00742 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17825767 | 0.86 | NOTUM (0.60) | NOTUMF9F10 | |
| SCHEMBL17185590 | 0.85 | MYC (0.56) | NOTUMF9F10 | |
| SCHEMBL17825744 | 0.83 | NOTUM (0.56) | NOTUMF9 | |
| SCHEMBL17185630 | 0.82 | NOTUM (0.54) | NOTUMF9F10 | |
| SCHEMBL3821527 | 0.80 | AVPR2 (0.52) | NOTUM | |
| SCHEMBL17188121 | 0.80 | NOTUM (0.77) | NOTUMF9F10 | |
| SCHEMBL17188181 | 0.78 | NOTUM (0.70) | NOTUMF9 | |
| SCHEMBL8168631 | 0.77 | F9 (0.49) | NOTUMF9 | |
| SCHEMBL16202026 | 0.77 | NOTUM (0.56) | NOTUM | |
| SCHEMBL17825734 | 0.76 | TSHR (0.53) | NOTUMF9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3229801-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2020-04-01 | — | — | EP | disclosed |
| US-10189819-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME, CORP. (US) | 2019-01-29 | — | — | US | disclosed |
| US-20180030036-A1 | Factor IXa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030036-A1 | Factor IXa Inhibitors | F9, TFPI, F12 | NOTUM 1991/4885F9 1/4885F10 5/4885 |
| US-10189819-B2 | Factor IXa inhibitors | F9, TFPI, F12 | NOTUM 1991/4885F9 1/4885F10 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.