Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 1.00 |
| ▸ | HMGCR | P04035 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | TSHR | P16473 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | MTOR | P42345 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mevastatin SCHEMBL13297669 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRSMN1; SMN2 | |
| Mevastatin SCHEMBL8277387 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRSMN1; SMN2 | |
| Mevastatin SCHEMBL13900408 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRSMN1; SMN2 | |
| Mevastatin SCHEMBL23936978 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRSMN1; SMN2 | |
| Mevastatin SCHEMBL1981409 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRSMN1; SMN2 | |
| Mevastatin SCHEMBL23636208 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRSMN1; SMN2 | |
| Mevastatin SCHEMBL21340588 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRSMN1; SMN2 | |
| Mevastatin SCHEMBL21340571 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRSMN1; SMN2 | |
| Mevastatin SCHEMBL21340628 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRSMN1; SMN2 | |
| Mevastatin SCHEMBL15091134 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373609-B1 | USE OF AMPHIPHILIC COMPOUNDS FOR CONTROLLED CRYSTALLIZATION OF STATINS AND STATIN INTERMEDIATES | KRKA D D NOVO MESTO (SI) | 2013-10-16 | — | — | EP | disclosed |
| EP-2327682-A1 | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates | KRKA, D.D., Novo Mesto (SI) | 2011-06-01 | — | — | EP | disclosed |