Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 3/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | AKT2 | P31751 | 3/20 | 0.33 |
| ▸ | WEE1 | P30291 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19816952 | 0.87 | FGFR1 (0.56) | FGFR1AURKAKDRAURKBSRC | |
| SCHEMBL21761868 | 0.81 | FGFR4 (0.36) | FGFR1AURKAKDRAURKBMAPT | |
| SCHEMBL19817044 | 0.80 | FGFR1 (0.50) | FGFR1AURKAKDRAURKBSRC | |
| SCHEMBL29536557 | 0.80 | FGFR1 (0.50) | FGFR1AURKAKDRAURKBSRC | |
| SCHEMBL19816981 | 0.75 | FGFR1 (0.37) | FGFR1MAPTALDH1A1PLA2G1BPOLB | |
| SCHEMBL23328706 | 0.75 | FGFR1 (0.50) | FGFR1AURKAKDRAURKBMAPT | |
| SCHEMBL21783951 | 0.74 | MEN1 (0.36) | FGFR1KDR | |
| SCHEMBL6073377 | 0.73 | MEN1 (0.38) | MAPTALDH1A1AKT1AKT2 | |
| SCHEMBL29537852 | 0.73 | MEN1 (0.38) | MAPTALDH1A1AKT1AKT2 | |
| SCHEMBL2893422 | 0.73 | AKT1 (0.48) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018023081-A1 | 6-PHENYLPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS AS ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2018-02-01 | — | — | WO | disclosed |