Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 3/20 | 0.35 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.33 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.33 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.33 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19818294 | 1.00 | TNF (0.45) | TNFALOX5APFEN1WDR5INPPL1 | |
| SCHEMBL19818295 | 1.00 | TNF (0.45) | TNFALOX5APFEN1WDR5INPPL1 | |
| SCHEMBL29794987 | 0.94 | TNF (0.50) | TNFALOX5APFEN1WDR5AOC3 | |
| SCHEMBL29794966 | 0.94 | TNF (0.50) | TNFALOX5APFEN1WDR5AOC3 | |
| SCHEMBL29794937 | 0.94 | TNF (0.50) | TNFALOX5APFEN1WDR5AOC3 | |
| SCHEMBL18157271 | 0.94 | TNF (0.50) | TNFALOX5APFEN1WDR5AOC3 | |
| SCHEMBL18145753 | 0.94 | TNF (0.50) | TNFALOX5APFEN1WDR5AOC3 | |
| SCHEMBL18145676 | 0.94 | TNF (0.50) | TNFALOX5APFEN1WDR5AOC3 | |
| SCHEMBL18145674 | 0.94 | TNF (0.50) | TNFALOX5APFEN1WDR5AOC3 | |
| SCHEMBL18145763 | 0.94 | TNF (0.50) | TNFALOX5APFEN1WDR5AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9879016-B2 | Indazolones as modulators of TNF signaling | ABBVIE INC. (US) | 2018-01-30 | — | — | US | disclosed |