Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17137360 | 1.00 | NR1H2 (0.54) | NR1H2PDE4BNAMPTRORCUSP2 | |
| SCHEMBL17137357 | 1.00 | NR1H2 (0.54) | NR1H2PDE4BNAMPTRORCUSP2 | |
| SCHEMBL19819953 | 0.88 | NR1H2 (0.48) | NR1H2PDE4BNAMPTRORCUSP2 | |
| SCHEMBL19211019 | 0.88 | NR1H2 (0.47) | NR1H2PDE4BNAMPTRORCUSP2 | |
| SCHEMBL30721755 | 0.85 | NR1H2 (0.65) | NR1H2PDE4BNAMPTRORCUSP2 | |
| SCHEMBL2930155 | 0.85 | NR1H2 (0.65) | NR1H2PDE4BNAMPTRORCUSP2 | |
| SCHEMBL2937360 | 0.85 | NR1H2 (0.65) | NR1H2PDE4BNAMPTRORCUSP2 | |
| SCHEMBL1014216 | 0.85 | NR1H2 (0.65) | NR1H2PDE4BNAMPTRORCUSP2 | |
| SCHEMBL30835821 | 0.84 | NR1H2 (0.59) | NR1H2PDE4BNAMPTRORCUSP2 | |
| SCHEMBL19123143 | 0.84 | NR1H2 (0.59) | NR1H2PDE4BNAMPTRORCUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9879022-B2 | Bicyclic-fused heteroaryl or aryl compounds | PFIZER INC. (US) | 2018-01-30 | — | — | US | disclosed |